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WHO-Klassifikation maligner Non-Hodgkin-Lymphome im Vergleich mit der R.E.A.L.- und der Kiel-Klassifikation

Autor/en: M. Uppenkamp
Letzte Änderung: 30.05.2003
Tabelle 5a: B-Zell-Lymphome nach WHO-, R.E.A.L.- und der updated Kiel-Klassifikation
WHO 2001R.E.A.L. 1994Updated Kiel 1988 and 1992
Precursor B-cell diseasesPrecursor B-cell diseases 
Precursor B-lymphoblastic lymphoma/ leukemiaPrecursor B-lymphoblastic lymphoma/ leukemiaB-lymphoblastic
Mature B-cell diseasePeripheral B-cell disease 
  • Chron. lymphocytic leukemia/
  • small lymphocytic lymphoma/
  • Prolympho-
    cytic leukemia
  • Chron. lymphocytic leukemia/
  • small lymphocytic lymphoma
  • Prolympho-
    cytic leukemia
  • Chron. lymphocytic leukemia;
  • Immunocytoma, lymphoplasma-
    cytoid typ;
  • Prolympho-
    cytic leukemia
Lymphoplasma-
cytic lymphoma/ Waldenström macroglobulinemia
Lymphoplasma-
cytic lymphoma/ Waldenström macroglobulinemia
Immunocytoma, lymphoplasmacytic type
Splenic marginal zone lymphomaSplenic marginal zone lymphoma (provisional) 
Hairy cell leukemiaHairy cell leukemiaHairy cell leukemia
Plasma cell neoplasmsPlasmacytoma/ myelomaPlasmacytic lymphoma
Extranodal marginal zone B-cell lymphoma of MALT typeExtranodal low grade B-cell lymphoma of MALT typeImmunocytoma/ MALT type lymphoma
Nodal marginal zone B-cell lymphomaNodal marginal zone B-cell lymphoma (provisional)Monocytoid, including marginal zone

Follicular lymphoma,
Variants:

  • grade 1,
  • grade 3 a and b

Follicle centre
lymphoma, Variants:

  • grade I, II
  • grade III
  • Centroblastic-
    centrocytic, follicular
    and diffuse
  • Centroblastic, follicular
Mantle cell lymphoma,
Variant: blastic
Mantle cell lymphomaCentrocytic

Diffuse large B-cell lymphoma
Variants:

  • centroblastic,
  • immunoblastic
  • T-cell or histiocyte rich
  • anaplastic large cell
Diffuse large B-cell lymphoma
  • Centroblastic,
  • B-immunoblastic,
  • B-large cell anaplastic
Mediastinal (thymic) large B-cell lymphomaPrimary mediastinal (thymic) large B-cell lymphoma 
Intravascular large B-cell lymphomaDiffuse large B-cell lymphomaAngio-endotheliotropic (intravascular) lymphoma
Primary effusion lymphoma  

Burkitt lymphoma (BL)
Variants:

  • BL with plasmacytoid differentiation,
  • atypical Burkitt/ Burkitt-like

Burkitt lymphoma
Variants:

  • high grade B-cell lymphoma,
  • Burkitt-like (provisional)
Burkitt and Burkitt lymphoma with intracytoplasmic immunoglobulin
Lymphomatoid granulomatosis  
Zur besseren Vergleichbarkeit wurden die englischen Bezeichnungen beibehalten.
Tabelle 6a: T-Zell-Lymphome nach WHO-, R.E.A.L.- und der updated Kiel-Klassifikation
WHO 2001R.E.A.L. 1994Updated Kiel 1988
Precursor T-cell diseasesPrecursor T-cell diseases 
Precursor T-lymphoblastic lymphoma/ leukemiaPrecursor T-lymphoblastic lymphoma/ leukemiaT-lymphoblastic
Mature T-cell/ NK-cell diseasePeripheral T-cell disease 
Prolymphocytic leukemiaProlymphocytic leukemia/ T-cell chronic lymphocytic leukemiaProlymphocytic leukemia/ T-cell lymphocytic leukemia, CLL type
T-cell large granular lymphocyte leukemiaLarge granular lymphocytic leukemia
(T-cell type)
 
Aggressive NK-cell leukemiaLarge granular lymphocytic leukemia
(NK-cell type)
 
Adult T-cell leukemia/ lymphoma
(HTLV-1+)
Adult T-cell leukemia/ lymphoma
(HTLV-1+)
T-cell lymphoma, small cell type, pleomorphic medium and large cell type (HTLV-1+)
Extranodal NK/ T-cell lymphoma, nasal typeAngiocentric T-cell lymphoma 
Enteropathy-type T-cell lymphomaIntestinal T-cell lymphoma 
Hepatosplenic T-cell lymphomaHepatosplenic γ/δ-T-cell lymphoma (provisional) 
Subcutaneous panniculitis-like T-cell lymphomaSubcutaneous panniculitic-like T-cell lymphoma (provisional) 
Blastic NK-cell lymphoma  
Mycosis fungoides and Sézary syndromeMycosis fungoides and Sézary syndromeSmall cell cerebriform (mycosis fungoides, Sézary syndrome)

Primary cutaneous CD30-positive T-cell lymphoproliferative disorders

  • primary cutaneous anaplastiv large cell lymphoma,
  • lymphomatoid papulosis
  
Angioimmuno-
blastic T-cell lymphoma
Angioimmuno-
blastic T-cell lymphoma
Angioimmuno-
blastic lymphadeno-
pathy

Peripheral T-cell lymphoma, unspecified;
Variants:

  • lymphoepithelioid cell,
  • T-zone lymphoma
Peripheral T-cell lymphoma, unspecified
  • T-zone lymphoma,
  • lymphoepitheloid cell (Lennert) lymphoma,
  • pleomorphic T-cell lymphoma (small, medium-sized, and large cell types),
  • T-immunoblastic
Anaplastic large cell lymphoma,
primary systemic
Anaplastic large cell lymphoma
(T/null-cell type)
Large cell anaplastic (Ki-1+)
Zur besseren Vergleichbarkeit wurden die englischen Bezeichnungen beibehalten.
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